Enzymuria in Gentamicin-Induced Kidney Damage

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Enzymuria in gentamicin-induced kidney damage.

To assess their potential value as early indicators of gentamicin-induced kidney damage, lysosomal hydrolases were measured in the 24-h urines of rats receiving 30 or 60 mg of gentamicin per kg per day for 15 days. Proteinuria, urine osmolality, blood urea nitrogen, and creatinine clearance were also measured. Kidney tissue was examined by both light and electron microscopy. Beta-galactosidase,...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1975

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.7.3.364